DescriptionAzathioprine is a purine analog and immunosuppressive antimetabolite that suppresses lymphocyte proliferation by inhibiting purine synthesis and incorporation of 6-thioguanine nucleotides into DNA and RNA. It is metabolized into 6?mercaptopurine and its active thioguanine nucleotides, reducing both cellular and humoral immune responses. In research, Azathioprine is often applied in models of autoimmune disease, organ transplantation, inflammatory bowel disease, myasthenia gravis, and JAK/STAT or NF??B pathway modulation. Provided as 50?mg scored tablets, 25 per box. For laboratory research use only. Contents hide 1 Product Specifications 2 Mechanism of Action & Research Applications 3 Side Effects (For Reference Only in Research Models) 4 Disclaimer Product SpecificationsParameterDetailProduct NameAzathioprine TabletsSynonymsAzathioprine; Imuran; 6-MP prodrug; Purine antimetaboliteStrength & Packaging50?mg per tablet, 25 tablets per boxDosage FormOral scored tabletManufacturerZhejiang Autocare Pharmaceutical Group Co., Ltd.Approval Number H33020153Drug Standard Code86904608000274Barcode6916370000035CAS Number446?86?6 (azathioprine sodium)Molecular FormulaC?H?N?O?SMolecular Weight~277.26?DaMechanism of Action & Research ApplicationsAzathioprine metabolizes into 6-mercaptopurine and thioguanine nucleotides which inhibit purine synthesis, suppress lymphocyte proliferation, and induce T-cell apoptosis via Rac1 signaling and NF??B pathway modulation. It is widely used in experimental immunology to model autoimmune disease, transplant rejection, inflammatory bowel disease, and cytokine-driven signaling research (e.g., JAK/STAT)Side Effects (For Reference Only in Research Models)Clinical analogs report myelosuppression (especially in TPMT or NUDT15-deficient models), increased infection risk, hepatotoxicity, gastrointestinal upset, headache, fever, rare malignancy risk, and risk of lymphoma – critical for defining safety thresholds in experimental protocols.DisclaimerAzathioprine Tablets are strictly intended for laboratory research use only. Not for clinical, veterinary, or diagnostic use.
