Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling Product SpecificationsAttributeDetailsProduct NameApomorphine Hydrochloride Sublingual TabletsGeneric NameApomorphine Hydrochloride (hemihydrate)CAS Number 41372-20-7Molecular FormulaC17H17NO2·HClMolecular Weight 303.78 g/molDosage FormSublingual tablet (film/tablet)Strength3mg per tabletPack Size1 tablet per boxApproval No.China NMPA H20050970Product Code86901828000640ManufacturerHubei Keyi Pharmaceutical Co., Ltd.Barcode6938399500952Storage ConditionsStore at 15–25°C in a cool, dry placeIntended UseLaboratory and preclinical research onlyMechanism of ActionApomorphine is a non-selective dopamine agonist with high affinity for D?–D? receptors and some serotonergic and adrenergic receptor activity. It mimics dopamine, alleviating motor “off” episodes in Parkinson’s disease models .Research Applications & PharmacologyParkinson’s Disease (PD) Models: Used to manage acute motor “off” episodes with rapid onset (~10–20 min), mimicking dopaminergic therapy .Pharmacokinetics & Comparison: Sublingual film/tablet provides similar efficacy to subcutaneous injection; widely preferred by patients in comparative studies pmc.ncbi.nlm.nih.gov 1en.wikipedia.org 1.Dose Titration: Standard clinical initiation begins at 10mg, optimized to 15–30mg sublingually; research-grade 3mg tablets can be used for precise titration .Additional Research Use: Investigated for erectile function modulation, addiction treatment, Alzheimer’s disease, and vomiting induction in veterinary models .Safety Profile & HandlingCommon Side Effects: Nausea (often requiring antiemetics), orthostatic hypotension, somnolence, dizziness, dyskinesia .Cardiac Effects: May cause QT prolongation—monitor cardiovascular parameters in research .Drug Interactions: Potentiates hypotension with nitrates/vasodilators; alcohol and dopamine antagonists may reduce efficacy or increase side effects .Handling Recommendations: Store protected from light and moisture; use PPE and lab-standard precautions. Discard expired items per institutional protocol.
